The staffing reductions were done through layoffs, not renewing contracts for some temporary faculty and attrition.
The cuts were announced in a letter Thursday by school President Michael Le Roy.
Calvin College has about 750 faculty and staff. The cost-cutting measures come as the Grand Rapids school looks to reduce long-term debt that grew to $115 million between 1997 and 2012.
It's also trimming its 2013-14 budget by $4.7 million.