The U.S. Fish and Wildlife Service said the lampricides will be placed in the waters June 17-21.
Sea lamprey are eel-like parasites that attach themselves to fish and suck out their bodily fluids. They live in stream sediments during their larval stage, the period that offers the best opportunity to kill them.
Infested tributaries must be treated every 3-5 years to keep lamprey numbers under control and avoid significant damage to fish populations.
Officials said the lampricides pose no unreasonable risk to people or the environment at concentrations necessary to kill larval lampreys.