The church was first organized in 1867. This past Sunday, its pews were packed with members of the congregation as the final service in its long history was held.
For many long-time members of the church, the final service was an emotional experience.
"I have very strong emotions about this being the last service," said Tom Cavanaugh, who has been a member of the church for 41 years. "This has been my church home and basically my family for a very long time."
Sunday's service was a special one, lasting about an hour and a half. It included singing, communion and sermons by several former pastors of the church. The Rev. Ecko DeVries, who served in the church for 13 years from 1974 to 1987, was one of those who spoke to the congregation.
"This service is the last worship service in this building," he said. "Next Sunday, all of us will be worshipping elsewhere. The end of the 146-year history of First Church is an emotionally heart wrenching experience to go through."
Many in attendance for the final service, such as Ron Rop, were returning after a long absence. Rop was baptized, raised and married in the church, but he left to attend a different church with his wife and children.
"It's kind of sad," he said. "I was here for 34 years before I went to a different church. And even though we've been gone so long I tear up when I'm here because so many things in my life have happened here. This is tough."
Church officials said dwindling membership, a lack of young people and financial issues are the main reasons the church is closing. However, the building will not be torn down and is currently for sale.
Pat Cavanaugh, who has played the organ in the church for 45 years, said possible uses for the building include the Christian schools like Muskegon Christian and Western Michigan Christian using it as an auditorium, but she hopes another pastor and church will buy it and continue to use it as a place of worship.
Regardless of what happens, Cavanaugh looks back on her time spent at the church with fond memories.
"This is pretty bittersweet," she said. "We've been truly blessed; this is a tremendous church community.
"I'm going to remember how loving these people are. People are always willing to step up when someone in the community needs. That kind of spirit has been here for a long time."