School board members on Monday approved sending the notices to about 40 teachers and other staffers, including paraprofessionals and student advocates. Other employees are affected.
Micky Savage, the district's director of human resources and labor relations, said Grand Rapids Public Schools hopes to get more students enrolled to bring some of the employees back.
The district is facing a $13.5 million operating deficit in its more than $200 million 2014-15 budget.
The planned layoffs aren't nearly as drastic as last summer, when the board sent notices to 216 staffers as it faced a projected enrollment decline of 700 students for the 2013-14 school year.