Emergency crews responded to the car vs. motorcycle crash at about 9:15 p.m.
The driver of the car was not injured.
Fruitport Township Police reported the motorcycle was westbound on Shettler Road. The Pontiac Grand Prix was eastbound on Shettler when the driver turned left onto Swanson Lane, into the path of the motorcycle.
The motorcyclist was thrown from his bike when the vehicles collided. He was not wearing a helmet.
An ambulance took him to Hackley Hospital in Muskegon. Police said he suffered multiple injuries.
Alcohol was not believed to be a factor in the crash.
Police did not release the names of the drivers.
The crash is still under investigation.
Anyone who may have witnessed the crash is asked to call Fruitport Township Police.