The highway's eastbound lanes were closed in the area of 48th Avenue near Coopersville.
Emergency crews from Marne and Coopersville started responding to the crash scene, near the 23-mile marker near Marne, at about 7:45 p.m.
A witness told WZZM-TV that the driver of an SUV used a restricted turn-around in the interstate, crossed over the freeway, went into a ditch and then started heading west in the eastbound lanes. The witness said several vehicles swerved out of the way to avoid the SUV before it finally slammed into a van, which caught fire.
The driver of the SUV was taken by the Aeromed helicopter to Spectrum Health Hospital in Grand Rapids. The westbound lanes were also closed for a short time to allow the helicopter to take off.
The driver of the van was killed in the crash.
The names of the people involved in the crash were not immediately released. We'll have more details when they become available.