The man’s name was not released.
Holland Police said alcohol was believed to be a factor in the crash.
The crash occurred about 9:05 p.m. in the area of 32nd Street near Apple Avenue.
Police said a 1993 GMC Suburban was eastbound on 32nd Street when witnesses saw it cross the centerline and crash head-on with the motorcycle.
Two of the three occupants of the Suburban fled the scene after the crash, but were apprehended a short time later about a quarter mile from the crash site.
All three individuals were taken into custody.
The crash remains under investigation. Anyone with information is asked to contact the Holland Department of Public Safety at 616-355-1100, or Silent Observer at 1-877-887-4536.