Rosemary Evans, who was ejected from the van, was pronounced dead at the scene.
Two other passengers were also injured in the 9:10 a.m. crash — Tawana Morris, 42, of Muskegon; and Jmiah Evans-Selmon, 2, also of Muskegon. Both were listed at a local hospital in critical but stable condition.
The driver of the van has been identified as Lateashia Evans-Selmon, 35, of Muskegon. She was treated at the scene, police said.
Harry Jones, 41, of Warren, was driving the semi and was not injured.
The crash remains under investigation. Anyone with information is asked to call the Muskegon Police Department at 231-724-6750 or Silent Observer at 231-722-7463.