The Cadillac News and the Traverse City Record-Eagle reported that the men were identified as 23-year-old Joshua Lester and 24-year-old Gary Helsel.
The crash happened early Tuesday in Cadillac. The vehicle carrying the Cadillac residents collided with a sport utility vehicle at an intersection before hitting the home.
The driver of the SUV was taken to a hospital.
A witness reported the SUV may have run a stop sign before the crash.