The accident happened around 6:45 p.m. on M-37, between 13 Mile Road and O’Connor Street, about 15 miles north of Grand Rapids.
State police said a 1999 Pontiac Bonneville driven by Ryan Anes, 34, from Grand Rapids crossed the centerline into the path of a 2007 Ford Focus driven by Wade Adams, 44, of Newaygo.
There were no passengers in either car.
Investigators said there are no signs that alcohol was a factor in the crash.
The Associated Press contributed to this report.