The crash happened around 5 p.m. on the off-ramp from eastbound Interstate 196 to Byron Road.
Ottawa County Sheriff’s deputies said the driver of a sport utility vehicle, Paula TerHaar, 49, exited the freeway to turn onto Byron Road, but she pulled into the path of a pickup driven by 38-year-old Kenneth Folkers.
TerHaar suffered a serious head injury and was flown by AeroMed to a Grand Rapids hospital for treatment. Folkers was not injured.
Both drivers were wearing their seat belts, police said.