Holland Township firefighters were called to help just after 8:30 p.m. and quickly doused the blaze. No one was injured.
The children in the home are all younger than 12, police said.
Ottawa County Sheriff's detectives have determined the fire was started by an arsonist and are investigating.
The same home, at 523 Butternut Ave. in Holland Township, was attacked Nov. 12, according to Lt. Mark Bennett.
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