Criminal homicides accounted for 386 of the 461 death investigations in 2012, Mayor Dave Bing announced Thursday. That was 42 more than the year before.
The city distinguishes criminal homicides, in which charges are or can be filed, from justifiable homicides.
"We've lost respect for each other. We've lost respect for life," Bing told reporters at City Hall.
Shootings accounted for 333 of last year's criminal homicides — up from 302 in 2011 and 254 in 2010.
"America has a problem with guns, but the epicenter seems to be here in Detroit," interim Police Chief Chester Logan said. "If I had 1,000 more police officers in the city of Detroit, I don't know what kind of impact it would have."
City officials said criminal homicides, robberies and car thefts increased last year even as overall crime declined by 2.5 percent.