Police said the tanker was stopped for a red light on northbound U.S. 31 at Felch Street in Holland Township at about 2:30 p.m. when a 2001 Ford Taurus ran into it from behind. The tanker was carrying polyalkylamine, a caustic substance, but it did not leak or spill, the Ottawa County Sheriff's Department said.
The driver of the car, whose name was not released, is listed in serious condition at the hospital.
A front-seat passenger, Angela Renea Brown, 23, and a back-seat passenger, Lajoyia Mitzenheimer, 30, were listed in good condition, police said. Both women are Holland Township residents.
The tanker driver, a Louisiana man, was not injured.
The Sheriff's Department is still investigating whether alcohol was a factor in the crash.