The crash occurred on the snowy highway near mile marker 23 early Wednesday afternoon.
Police and firefighters reported other slide-offs along the highway.
Robinson Township firefighters responded to a two-car crash about the same time on M-45 between 120th and 128th avenues.
Police are asking motorists to drive with caution on the slippery roads.
West Michigan received several inches of Lake effect snow overnight and on Christmas Day.
A motorist traveling from Ionia to the Lansing area said snow was very light, but the wind was picking up.