The 69-year-old woman's name is Brookie Rae Boyer.
A section of the two-lane highway between 112th and 104th avenues was closed for nearly three hours after the 7:15 p.m. crash.
Ottawa County Sheriff’s deputies said Boyer was driving a 2004 Chevrolet Malibu east on M-45 when she crossed the center line and was struck by a westbound 2003 Chevrolet Tahoe driven by Stephen Molitor, 24, of Grand Haven. The cars collided almost head-on.
The Tahoe spun around and stopped facing east in the westbound lane. The car also spun and traveled backward down the road and up into a snow bank, taking out a row of mailboxes along the way.
Boyer was pronounced dead at the scene by an Ottawa County medical examiner.
Molitor suffered bumps and bruises, and was treated by paramedics and released. He appeared shaken, but was walking around at the scene.
Both drivers were the only occupants of their cars. Police said they both were wearing seat belts.
Once the medical examiner was done, firefighters used hydraulic tools to cut apart the car to extricate the woman's body shortly before 9 p.m.
"M-45 was clear and dry of any ice and snow," said Sgt. Steve Austin in describing road conditions at the crash site. "Alcohol appeared not to be a factor in the crash."