The awards were announced in a ceremony Friday night at the former Grand Rapids Press building.
Khare's winning work is a 35-by-8-foot carbon pencil on paper drawing of elephants and other animals. She described her large-scale work as a "series of life-sized elephants, intertwined with a menagerie of animals."
Khare said she worked on "Elephants" for 18 months. It is on display at the Grand Rapids Art Museum.
Second place, and a $75,000 prize, was determined by the public vote. "Song of Lift" by Martijn van Wagtendonk of Colbert, Ga., took that award. The kinetic sculpture involves mechanical birds, light and Henryk Gorecki's Symphony No. 3, "Symphony of Sorrow Songs." It is on display at the Urban Institute for Contemporary Arts.
The third place $50,000 winner is "Rebirth of Spring," a painting by Fritz Hoendervanger of Detroit. It is on display at the Amway Grand Plaza Hotel.
ArtPrize remains open this weekend.