Detroit led 6-0 after three innings, but Oakland came back to tie it at 7-all in the seventh. Lowrie — whose ninth-inning homer gave the A's a victory at Detroit on Monday — singled home Matt Joyce in the ninth. It was Lowrie's fourth hit of the night.
Joyce doubled off Shane Greene (2-5) to lead off the ninth. Lowrie also came in to score an insurance run on a single by pinch-hitter Dustin Fowler.
Chad Pinder and Lowrie hit consecutive homers in the fifth for the A's, who extended their record streak to 27 straight road games with a home run.
Ryan Buchter (2-0) pitched a scoreless eighth for Oakland, and Blake Treinen finished for his 19th save in 21 chances.
The Tigers scored four runs in the first. Nicholas Castellanos hit an RBI double, and Niko Goodrum drove in two runs with a double of his own. James McCann's RBI single made it 4-0.
Dixon Machado added a two-run triple in the third for Detroit.
Oakland starter Frankie Montas allowed six runs and eight hits in three innings.
Blaine Hardy was breezing along for the Tigers until he gave up three unearned runs in the fourth. First baseman John Hicks mishandled a throw for an error with two outs. Mark Canha followed with an RBI double, and Jonathan Lucroy added a two-run double to make it 6-3.
Hicks rebounded a bit with an RBI single in the bottom of the fourth, but Hardy didn't retire a batter in the fifth. Pinder hit a two-run homer, and Lowrie followed with a solo shot to make it 7-6. Hardy was taken out after a walk to Khris Davis, and Buck Farmer came on in relief and shut the A's out for two innings.
Oakland finally tied it in the seventh. With rain coming down hard at times, Detroit reliever Louis Coleman had all sorts of problems. He got only one out and allowed a single and two walks. Alex Wilson took his place with the bases loaded and allowed a run-scoring grounder by Matt Olson.
Hicks struck out with the bases loaded to end the eighth.
Tigers: LHP Daniel Stumpf, on the disabled list with ulnar nerve irritation, made a rehab appearance Monday night with Triple-A Toledo. He threw 1 2/3 hitless innings against Indianapolis.
Oakland LHP Sean Manaea (7-6) takes the mound Wednesday night against Detroit RHP Mike Fiers (5-4). Manaea is 2-0 this month with a 2.81 ERA.