The third-seeded Wolverines were up to the test much of the first half. They frustrated Villanova star guard and national player of the year Jalen Brunson, and limited star forward Mikal Bridges.
But Michigan had no answer for Villanova sixth man Donte DiVincenzo, who keyed a backbreaking 23-7 run and hit clutch shot after clutch shot to push the Wildcats past the Wolverines, 79-62, in the national title game Monday at the Alamodome.
Muhammad-Ali Abdur-Rahkman scored 23, Moritz Wagner 16 and Zavier Simpson 10 for Michigan (33-8), which shot 3-for-23 from 3-point range and fell to 1-6 all-time in the national championship game.
DiVincenzo finished with 31 points (10-for-15 shooting) and Bridges scored 19 for Villanova (36-4), which shot 47.4 percent (27-for-57) from the field and won its second title in three seasons.
After Michigan struggled to close out the first half and Villanova's offense began to heat up, the Wildcats picked right up where they left off in the second half.
Within the blink of an eye, Villanova ripped off seven straight points – five from Eric Paschall on a 3-pointer and layup – to quickly extend its lead to 44-30 and put Michigan in danger with 18:11 to play.
Matters continued to worsen for Michigan as Wagner drew an offensive foul and a technical foul – along with Villanova's Omari Spellman – on the same play and the Wildcats used a 3-pointer by Bridges two possessions later to push their advantage to 51-33 at the 14:37 mark.
The Wolverines used an 8-3 run with four points from Charles Matthews on a dunk and layup to gain some semblance of momentum and claw within 56-44 with 9:08 to go.
But DiVincenzo quickly stemmed the tide with a pair of dagger 3-pointers – and a wink as he trotted back down the court – to put Villanova up 62-44 a minute later.
Abdur-Rahkman made four free throws to cut the deficit to 14 at the 6:43 mark before Bridges drove a stake into Michigan's title hopes with a pair of deep 3-pointers during a 10-2 surge that put the game out of reach, 74-52, with 3:50 to go.
The first six minutes unfolded like a heavyweight title bout as both teams came out swinging. Brunson went right at Simpson and knocked down two tough baskets on Villanova's first two possessions of the game.
Wagner countered with nine points on a pair of layups, two free throws and a 3-pointer and Abdur-Rahkman knocked down a deep ball as Michigan got off to a hot start and roared out to a 14-8 lead with 13:17 left in the first half.
Michigan's defense, meanwhile, dug in and forced Villanova to miss its first four attempts from deep before DiVincenzo snapped the drought with a 3-pointer and converted a three-point play to cut the deficit to 16-14 at the 12:06 mark.
The Wolverines continued to take the fight to the Wildcats with five straight points to grab their largest lead of the half, 21-14, after Jordan Poole knifed his way to a basket for a nifty layup plus the foul and Wagner scored on another layup with 10:59 left.
But Villanova's defense eventually began to figure things out and Michigan's offense cooled off dramatically. The Wolverines missed 13 of their final 16 shots of the half with a pair of three-plus minute scoring droughts sprinkled in.
The Wildcats took full advantage of the cold spells and began to wear down the Wolverines while closing the half on a 23-7 run. It started with a 9-0 flurry that began with a jumper and ended with a 3-pointer by DiVincenzo to put Villanova ahead, 23-21, at the 6:08 mark.
Abdur-Rahkman provided a brief respite and snapped a 0-for-7 shooting slide for Michigan with a driving layup to tie the game before DiVincenzo struck again with five straight points for Villanova on a 3-pointer and layup to make it 30-26 with 4:07 left in the half.
The Wolverines pulled within 30-28 at the 3:34 mark following a Matthews dunk, but hit another rough patch and missed their last six shots. Villanova made Michigan pay as Brunson capped a 7-0 run with a 3-pointer to put the Wolverines in a 37-28 hole at the break.