The city wasn't selected as one of the four host cities for the 2023-26 Final Fours, unveiled by the NCAA on Monday afternoon.
Houston, Phoenix, San Antonio and Indianapolis were chosen by the NCAA as the four hosts of the 2023-26 events, respectively. Detroit was left out along with other finalists Los Angeles and Dallas.
"While we were eagerly looking forward to a more favorable outcome, we are proud of and grateful for the efforts put forward by the Big Ten, Michigan State University and the Detroit Sports Organizing Corp. to bring the NCAA Men's Final Four back to Detroit," Detroit Sports Commission Director Kris Smith said in a statement.
"We thank the NCAA Division I Men's Basketball Committee for allowing us to showcase the city of Detroit and present its viability as a premier event location. We look forward to continued collaboration with the NCAA on future men's basketball events, while teaming to host seven upcoming NCAA championship events in Detroit."
Detroit was named one of seven finalists last week, according to reports from the Detroit Free Press and Detroit News among others. That came after members of the NCAA made a site tour to Detroit and Ford Field.
Detroit previously hosted the 2009 Final Four at Ford Field, where Michigan State made the national championship game before falling to North Carolina.
Since then, the facility has undergone $100 in renovations that include new premium seating, new video boards, enhanced wireless internet and more, putting it in the conversation for a repeat visit.
Now, it will have to wait until the next four year of bids are announced to have a shot at another Final Four.
The Final Four is set to be held in Minneapolis in 2019, followed by Atlanta in 2020, Indianapolis in 2021 and New Orleans in 2022.
Even without the Final Four, Detroit will still host several big-name athletic events in the coming years, particularly following the opening of Little Caesars Arena last year. The arena is set to host the 2020 Frozen Four and NCAA Tournament games in 2021.
Former Michigan State athletic director Mark Hollis also indicated last year that LCA would push to host the Big Ten basketball tournament in coming years.