It happened at around 8:45 a.m. on eastbound I-96 near Walker Avenue. Michigan State Police troopers said it started when some drivers did not slow down for a backup at the Walker exit.
Five vehicles, including two semi-trucks, were involved in the crash. Two people were taken to an area hospital, but they're expected to recover.
Troopers reopened the eastbound side of the freeway shortly before noon.