The crash occurred at about 3:40 a.m. on the two-lane highway between Allendale and Walker.
The deceased woman’s name, and the name of the at-fault driver, were not released.
The woman, in a 2014 GMC Terrain, was driving east on Lake Michigan Drive, when a westbound 2016 Jeep Wrangler, driven by a 25-year-old Greenville man, crossed the center line and struck her vehicle head-on, according to Sgt. Jay Douglas of the Ottawa County Sheriff’s Office.
The woman was pronounced dead at the scene, Douglas said. The man was pinned inside his vehicle. After being extricated by firefighters, he was transported to Spectrum Butterworth Hospital in Grand Rapids in serious, but stable condition.
Douglas said that alcohol, used by the Greenville man, was a factor in the crash.
Lake Michigan Drive was closed for several hours during the crash investigation and re-opened Sunday morning at about 7:20 a.m.
The crash remains under investigation.